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sparsentan will lessen the level or effect of modafinil by impacting hepatic enzyme CYP2C19 metabolism. Use Warning/Observe. Sparsentan (a CYP2C19 inducer) decreases publicity of CYP2C19 substrates and minimizes efficacy linked to these substrates.Modafinil may well lessen serum concentrations of other prescription drugs to some clinically consider